Metrogel Drug Interactions
A few products may cause adverse reactions with Metrogel. Problems may occur if this rosacea medicine is used in combination with products such as alcohol, lithium, or warfarin. Some of these combinations may lead to drug interactions with Metrogel, potentially increasing your risk for side effects like bleeding or hallucinations.
An Overview of Interactions With MetrogelMetrogel® (metronidazole gel) may react with a few other medications. Some of the drugs that may interact with Metrogel include but are not limited to:
- Amprenavir oral solution (Agenerase®)
- Disulfiram (Antabuse®)
- Eplerenone (Inspra™)
- Lithium (Eskalith®, Lithobid®)
- Maraviroc (Selzentry™)
- Ranolazine (Ranexa®)
- Warfarin (Coumadin®, Jantoven®).
Metrogel Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Metrogel is combined with any of the drugs listed above.
The standard recommendation is that people taking metronidazole products, including Metrogel, should not drink alcohol. However, this type of interaction is probably unlikely to occur when metronidazole is applied to the skin (such as with Metrogel), although this is not known for sure. In addition, there is some uncertainty about the validity of this interaction (see Metronidazole and Alcohol).
Combining Metrogel with amprenavir oral solution (but not the other forms of amprenavir) can interact dangerously with metronidazole (the active ingredient in Metrogel). It is unclear whether this interaction applies to the skin formulations of metronidazole (such as Metrogel), as only a small amount of the medication is absorbed from the skin into the bloodstream. Check with your healthcare provider before using these medications together.