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Oracea Warnings and Precautions

There are several warnings and precautions to be aware of with Oracea, including an increased risk of ulcers, the danger of taking the medication if you are pregnant, and potential drug interactions. You should not take Oracea if you are allergic to any components of the medicine. Before taking Oracea, make sure to tell your healthcare provider if you have kidney or liver disease.

What Should I Tell My Healthcare Provider Before Taking Oracea?

You should talk to your healthcare provider prior to taking Oracea® (doxycycline) if you have:
  • Kidney disease such as kidney failure (renal failure)
  • Frequent yeast infections
  • Liver disease or liver failure
  • Any other allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Oracea Precautions and Warnings

Precautions and warnings to be aware of prior to taking Oracea include the following:
  • Oracea is considered pregnancy Category D medicine. This means that there is significant risk to an unborn baby. If you are pregnant, discuss these risks with your healthcare provider before using Oracea (see Doxycycline and Pregnancy for more information).
  • Taking Oracea during pregnancy or before the age of eight may cause permanent discoloring of teeth in the infant or child.
  • To avoid ulcers and esophageal pain while taking Oracea, make sure to drink plenty of fluids with your medicine. Do not take this medication lying down, and do not lie down immediately after taking the drug. These measures are necessary to make sure that the Oracea capsule does not accidentally stick in your throat, where it could cause significant irritation and damage.
  • Oracea can interact with certain medications (see Oracea Drug Interactions).
  • If you have kidney disease or severe liver disease, your healthcare provider may choose to give you a lower dose than normal or not prescribe the drug at all.
  • It is known that Oracea passes through breast milk. Therefore, if you are breastfeeding, be sure to check with your healthcare provider before taking Oracea (see Doxycycline and Breastfeeding).
  • Many antibiotics have been known to cause pseudomembranous colitis (severe diarrhea). If you experience such symptoms, contact your healthcare provider immediately.
  • While taking antibiotics such as Oracea, other infections have been known to occur (vaginal yeast infections, etc.). If you notice symptoms unrelated to your original condition, talk to your healthcare provider.
  • Antibiotics have been known to cause increased pressure in the skull. This usually stops when the antibiotic is discontinued. Make sure to talk to your healthcare provider if you experience any of the following symptoms while taking Oracea:


    • Headaches
    • Blurred vision
    • Nausea
    • Vomiting
    • Dizziness.


  • Skin reactions that resemble serious sunburns may occur if you are exposed to sunlight while taking Oracea. Try to avoid unnecessary sunlight exposure while taking this antibiotic. If sunlight exposure is unavoidable, cover as much of your skin as possible (long sleeves, long pants, or a hat), and use a sunscreen with a rating of SPF 45 or higher.
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